What are the warning signs of rhabdomyolysis? Rhabdomyolysis is characterized by particularly intense muscle pain of sudden onset accompanied by difficulty moving. If you notice these symptoms you should immediately contact your doctor. At the biological level, rhabdomyolysis is always accompanied by a significant increase in CPK. What is CPK? What is the usefulness of their dosage? The KPC, for creatine kinase, are muscle enzymes. When muscle cells are destroyed, the CPK is released into the bloodstream and their blood concentration is increased. In practice, the CPK rise in blood at any muscle damage: those related to taking statins, but also has a myocardial infarction (heart muscle), muscle trauma, a genetic muscle disease, etc. Similarly, an intense physical activity or sport can cause a significant increase in CPK sometimes and always transient. .
Some people have more risk of having a muscular problem? Although adverse muscle effects of statins are rare, some people are more likely than others to experience this type of problem: subjects with personally or with a member their families suffering from a genetic muscle disease, subjects with hypothyroidism and not taking treatment, in case of renal failure, in case of excessive alcohol consumption, subjects aged 70 years and more especially if there are other risk factors for muscle, subjects with skeletal muscle effects already present as a result of cholesterol-lowering therapy (with another statin or fibrate). For these patients, the doctor will prescribe a blood CPK control before starting treatment. Other situations may increase the frequency of occurrence of these adverse reactions muscle: taking other drugs (like fibrates) at the same time a statin, taking high doses of statins (80 mg).
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